PRESTO Inclusion/Exclusion Criteria

The PRESTO model was derived on subjects that did not have any of the following:
  • Small Duct PSC
  • Another concurrent liver disease including overlap with Autoimmune Hepatitis
  • MELD score greater than 14 at baseline
  • Prior Liver Transplantation
  • Presence of Portal Hypertension (varices, ascites, encephalopathy, splenomegaly, or platelets less than 150 x 10^9/L) at baseline
  • Subjects less than 18 years of age
If a person has any of the above, then the calculator may not be valid since PRESTO was not tested under these baseline conditions.

Subject 1 Input Parameters

Subject 2 Input Parameters

PRESTO Inclusion/Exclusion Criteria

The PRESTO model was derived on subjects that did not have any of the following:
  • Small Duct PSC
  • Another concurrent liver disease including overlap with Autoimmune Hepatitis
  • MELD score greater than 14 at baseline
  • Prior Liver Transplantation
  • Presence of Portal Hypertension (varices, ascites, encephalopathy, splenomegaly, or platelets less than 150 x 10^9/L) at baseline
  • Subjects less than 18 years of age
If a person has any of the above, then the calculator may not be valid since PRESTO was not tested under these baseline conditions.


Reference:

Eaton JE, Vesterhus M, McCauley BM, Atkinson EJ , Schlicht EM, Juran BD, Gossard AA, LaRusso NF, Gores GJ, Karlsen TH, Lazaridis KN.
Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes in PSC: A Derivation & Validation Study Using Machine Learning.
Hepatology. 2018 May 9 Epub 2018 May 09
PeerReviewArticle Pub Med , Doi

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App Maintainer: Bryan McCauley (mccauley.bryan@mayo.edu)